I've been working on the performance of my websites, all of them Drupal powered, and all hosted on Dreamhost VPS. The latest step was to move over to PHP 5.3, use APC, use memcache, use the Drupal module for memcache, and oh I also installed the "upload progress" PECL module along the way to get a status report entry to shut up. There are two ways to get better performance, right? One is to buy more servers and install a distributed infrastructure. The other is optimizing the software. A recent podcast from Lullabot said "APC, Memcache, and Varnish".
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